Cholera first appeared in Britain in 1831, originating from India, where it had spread across Europe during a time of increasing global mobility. Subsequent outbreaks of cholera occurred throughout the nineteenth century, most notably in 1848-49. The Spanish flu pandemic of 1918-20 marked a culmination of a century of infectious disease and subsequent burial reform. These diseases not only claimed countless lives, but they also overwhelmed local authorities and an infant and overstretched burial industry. Somewhat out of necessity, and partly through scientific and practical advancement, the period 1832-1920 witnessed an evolution in how diseased cadavers were handled and laid to rest. This paper will explore the care and burial of diseased cadavers during this period. Reference will also be made to the introduction of new cemeteries and the campaign for municipal crematoriums, as a direct response to disease. This exploration will be conducted through the lens of two contrasting English regions: East Yorkshire and Nottinghamshire. Both regions employed different strategies to provide appropriate care of diseased cadavers, but their conundrum remained the same: a lack of suitable burial space. This problem had profound implications on both the storage of diseased cadavers and the manpower required to handle the resulting backlog. This will highlight the necessity for burial reform and society’s speed of change in this crucial area. This paper will subsequently explore the care and burial of diseased cadavers in both regions with particular focus on the 1832 and 1848-49 cholera epidemics and the Spanish flu pandemic of 1918-20.